2023
2022
. Annual Review of Phytopathology. Aug 26;60:211-236. doi: 10.1146/annurev-phyto-021621-121935.
*corresponding authors
. PLoS Pathogens. Jul 25;18(7):e1010716. doi: 10.1371/journal.ppat.1010716.
. PLoS Pathogens. May 16;18(5):e1010541. doi: 10.1371/journal.ppat.1010541.
*corresponding authors
. Scientific Reports. Apr 20;12(1):6534. doi: 10.1038/s41598-022-10410-w.
*corresponding authors
. PLoS Computational Biology. Feb 22;18(2):e1009899. doi: 10.1371/journal.pcbi.1009899.
2021
The small molecule Zaractin activates ZAR1-mediated immunity in Arabidopsis.Proceedings of the National Academy of Science U S A. Nov 23;118(47):e2116570118. doi: 10.1073/pnas.2116570118.
The ETS-ETI cycle: evolutionary processes and metapopulation dynamics driving the diversification of pathogen effectors and host immune factors. Current Opinion in Plant Biology Aug;62:102011. doi: 10.1016/j.pbi.2021.102011.
*corresponding authors
Biotin-Based Proximity Labeling of Protein Complexes in Planta. Methods in Molecular Biology; 2200:425-440. doi: 10.1007/978-1-0716-0880-7_21.
2020
Laflamme B., Dillon M.M., Martel A., Almeida R.N.D., Desveaux D.*, Guttman D.S.* (2020) The pan-genome effector-triggered immunity landscape of a host-pathogen interaction. Science. Feb 14;367(6479):763-768.
*corresponding authors
Martel A., Laflamme B., Seto D., Bastedo D.P., Dillon M.M., Almeida R.N.D., Guttman D.S., Desveaux D. (2020) Immunodiversity of the Arabidopsis ZAR1 NLR Is Conveyed by Receptor-Like Cytoplasmic Kinase Sensors. Frontiers in Plant Science Aug 21;11:1290. doi: 10.3389/fpls.2020.01290.
Martel A., Lo T., Desveaux D.*, Guttman D.S.* (2020) A High-Throughput, Seedling Screen for Plant Immunity. Molecular Plant Microbe Interactions. Jan 23:MPMI10190295TA.
*corresponding authors
The Arabidopsis ZED1-Related Kinase Genomic Cluster Is Specifically Required for Effector-Triggered Immunity. Plant Physiology Dec;184(4):1635-1639.
2019
Bastedo D.P., Khan M., Martel A., Seto D., Kireeva I., Zhang J., Masud W., Millar D., Lee J.Y., Lee A.H., Gong Y., Santos-Severino A., Guttman D.S., Desveaux D. (2019) Perturbations of the ZED1 pseudokinase activate plant immunity. PLoS Pathogens. Jul 3;15(7):e1007900.
Bastedo D.P., Lo T., Laflamme B., Desveaux D.*, Guttman D.S.* (2019) Diversity and Evolution of Type III Secreted Effectors: A Case Study of Three Families. Current Topics in Microbiology and Immunology. Jun 26.
*corresponding authors
Mogg C., Bonner C., Wang L., Schernthaner J., Smith M., Desveaux D.*, Subramaniam R.* (2019) Genomic Identification of the TOR Signaling Pathway as a Target of the Plant Alkaloid Antofine in the Phytopathogen Fusarium graminearum. MBio. 2019 Jun 11;10(3). pii: e00792-19.
*corresponding authors
Cao F.Y., Khan M., Taniguchi M., Mirmiran A., Moeder W., Lumba S., Yoshioka K., Desveaux D. (2019) A host-pathogen interactome uncovers phytopathogenic strategies to manipulate plant ABA responses. The Plant Journal May 31.
Dillon M.M., Almeida R.N.D., Laflamme B., Martel A., Weir B.S., Desveaux D., Guttman D.S. (2019) Molecular Evolution of Pseudomonas syringae Type III Secreted Effector Proteins. Frontiers in Plant Science. Apr 5;10:418.
Mott G.A., Smakowska-Luzan E., Pasha A., Parys K., Howton T.C., Neuhold J., Lehner A., Grünwald K., Stolt-Bergner P., Provart N.J., Mukhtar M.S., Desveaux D., Guttman D.S., Belkhadir Y. (2019) Map of physical interactions between extracellular domains of Arabidopsis leucine-rich repeat receptor kinases. Scientific Data. Feb 26;6:190025.
Lee A.H., Bastedo D.P., Youn J.Y., Lo T., Middleton M.A., Kireeva I., Lee J.Y., Sharifpoor S., Baryshnikova A., Zhang J., Wang P.W., Peisajovich S.G., Costanzo M., Andrews B.J., Boone C.M., Desveaux D.*, Guttman D.S.* (2019) Identifying Pseudomonas syringae Type III Secreted Effector Function via a Yeast Genomic Screen. G3. Feb 7;9(2):535-547.
*corresponding authors
2018
Cao F.Y., DeFalco T.A., Moeder W., Li B., Gong Y., Liu X.M., Taniguchi M., Lumba S., Toh S., Shan L., Ellis B., Desveaux D.*, Yoshioka K.* (2018) Arabidopsis ETHYLENE RESPONSE FACTOR 8 (ERF8) has dual functions in ABA signaling and immunity. BMC Plant Biology. 18(1):211
*corresponding authors
Khan M., Youn J.Y., Gingras A.C., Subramaniam R., Desveaux D. (2018) In planta proximity dependent biotin identification (BioID). Scientific Reports. Jun 15;8(1):9212.
Mirmiran A., Desveaux D., Subramaniam R. (2018) Building a protein-interaction network to study Fusarium graminearum pathogenesis. Canadian Journal of Plant Pathology. 40(2): 172-178.
Smakowska-Luzan E., Mott G.A., Parys K., Stegmann M., Howton T.C., Layeghifard M., Neuhold J., Lehner A., Kong J., Grünwald K., Weinberger N., Satbhai S.B., Mayer D., Busch W., Madalinski M., Stolt-Bergner P., Provart N.J., Mukhtar M.S., Zipfel C., Desveaux D.*, Guttman D.S.*, Belkhadir Y.* (2018) An extracellular network of Arabidopsis leucine-rich repeat receptor kinases. Nature. Jan 10; doi: 10.1038/nature25184.
*corresponding authors
Mott G.A., Desveaux D., Guttman D.S. (2018) A high-sensitivity, microtiter-based plate assay for plant MAMP-triggered immunity. Molecular Plant Microbe Interactions. May;31(5):499-504.
Khan M., Seto D., Subramaniam R.*, Desveaux D.* (2018) Oh, the places they’ll go! A survey of phytopathogen effectors and their host targets. The Plant Journal. Feb;93(4):651-663.
*corresponding authors
2017
Mott G.A., Guttman D.S., Desveaux D. (2017) The study of pattern-triggered immunity in Arabidopsis. Canadian Journal of Plant Pathology. 39(3): 275-281.
Gong Y., Desveaux D., Guttman D.S., Lewis J.D. (2017) A Practical Guide to Quantitative Interactor Screening with Next-Generation Sequencing (QIS-Seq). Methods in Molecular Biology. 1613; 1-20.
Seto D., Koulena N., Lo T., Menna A., Guttman D.S., Desveaux D. (2017). Expanded Type III Effector Recognition by the ZAR1 NLR Protein Using ZED1-Related Kinases. Nature Plants. Mar 13;3:17027.
Lo T., Koulena N., Seto D., Guttman D.S.*, Desveaux D.* (2017). The HopF family of Pseudomonas syringae type III secreted effectors. Molecular Plant Pathology.May 9;17:98.
*corresponding authors
2016
Laflamme B., Middleton M., Lo T., Desveaux D.*, Guttman D.S.* (2016). Image-Based Quantification of Plant Immunity and Disease. Molecular Plant Microbe Interactions. Dec;29(12):919-924.
*corresponding authors
Austin R.S., Hiu S., Waese J., Ierullo M., Pasha A., Wang T., Fan J., Foong C., Breit R., Desveaux D., Moses A., Provart N.J. (2016). New BAR Tools for Mining Expression Data and Exploring Cis-Elements in Arabidopsis thaliana. The Plant Journal. Jul 12. doi: 10.1111/tpj.13261.
Zhou X., Zhang Z.L., Yusuke J., Qiu K., Park J., Nam E.A., Lumba S., Desveaux D., McCourt P., Kamiya Y., Tyler L., Sun T.P. (2016). ERF11 Promotes Internode Elongation by Activating Gibberellin Biosynthesis and Signaling Pathways in Arabidopsis. Plant Physiology. Jun 2. pii: pp.00154.2016.
Mott G.A., Thakur S., Wang P.W., Desveaux D.*, Guttman D.S.* (2016). Genomic screens identify a new phytobacterial MAMP and an Arabidopsis receptor-like kinase required for immune elicitation. Genome Biology. May 9;17(1):98. doi: 10.1186/s13059-016-0955-7.
*corresponding authors
Khan M., Subramaniam R.*, Desveaux. D.* (2016). Of Guards, Decoys, Baits and Traps: Pathogen Perception in Plants by Type III Effector Sensors. Current Opinion in Microbiology. Feb;29: 49-55. doi: 10.1016/j.mib.2015.10.006.
*corresponding authors
2015
Menna A., Nguyen D., Guttman D.S., Desveaux D. (2015). Elevated temperature differentially influences effector-triggered immunity outputs in Arabidopsis. Frontiers in Plant Science. Nov 9;6:995. doi: 10.3389/fpls.2015.00995. eCollection 2015.
2014
Hurley B, Lee D, Mott A, Wilton M, Liu J, Liu YC, Angers S, Coaker G, Guttman DS, Desveaux D. (2014). The Pseudomonas syringae Type III Effector HopF2 Suppresses Arabidopsis Stomatal Immunity. PLoS One Dec 11; 9(12):e114921.
Mott GA, Middleton MA, Desveaux D, Guttman DS. (2014). Peptides and small molecules of the plant-pathogen apoplectic arena. Frontiers in Plant Science Nov 28; 5:677.
Hurley B, Subramaniam R, Guttman DS, Desveaux D. (2014). Proteomics of effector-triggered immunity (ETI) in plants. Virulence Sept 23; 5(7).
Chang J.H., Desveaux D., Creason A.L. (2014). The ABCs and 123s of bacterial secretion systems in plant pathogenesis. Annual Review of Phytopathology 52:317-345.
Lumba S., Toh S., Handfield L.F., Swan M., Liu R., Youn J.Y., Cutler S., Subramaniam R., Provart N., Moses A., Desveaux D.*, McCourt P.* (2014). A meso-scale abscisic acid hormone interactome reveals a dynamic signaling landscape in Arabidopsis. Developmental Cell 29:360-372. *corresponding authors
Yu C.G., Tonikian R., Felsensteiner C., Jhingree J.R., Desveaux D., Sidhu S.S., Harris T.J. (2014). Peptide binding properties of the three PDZ domains of bazooka (Drosophila par-3). PLoS One. Jan 22;9(1):e86412.
Lewis JD, Lo T, Bastedo P, Guttman DS, Desveaux D. (2014). The rise of the undead: Pseudokinases as mediators of effector-triggered immunity. Plant Signaling Behavior. 2014 Jan 7;8(12).
Austin RS, Chatfield SP, Desveaux D, Guttman DS. (2014). Next-generation mapping of genetic mutations using bulk population sequencing. Methods in Molecular Biology 1062:301-15.
Murmu J, Wilton M, Allard G, Pandeya R, Desveaux D, Singh J, Subramaniam R. (2014). Arabidopsis GOLDEN2-LIKE (GLK) transcription factors activate jasmonic acid (JA)-dependent disease susceptibility to the biotrophic pathogen Hyaloperonospora arabidopsidis, as well as JA-independent plant immunity against the necrotrophic pathogen Botrytis cinerea. Molecular Plant Pathology. Feb;15(2):174-84.
2013
Lewis JD, Lee AH, Hassan JA, Wan J, Hurley B, Jhingree JR, Wang PW, Lo T, Youn JY, Guttman DS, Desveaux D. (2013). The Arabidopsis ZED1 pseudokinase is required for ZAR1-mediated immunity induced by the Pseudomonas syringae type III effector HopZ1a. Proceedings of the National Academy of Sciences USA 110(46):18722-18727.
Lee AH, Middleton MA, Guttman DS, Desveaux D. (2013). Phytopathogen type III effectors as probes of biological systems. Microbial Biotechnology 1062:301-15.
2012
Schreiber KJ, Austin RS, Gong Y, Zhang J, Fung P, Wang PW, Guttman DS, Desveaux D. (2012). Forward chemical genetic screens in Arabidopsis identify genes that influence sensitivity to the phytotoxic compound sulfamethoxazole. BMC Plant Biology Nov 24;12:226.
Schreiber KJ, Ye D, Fich E, Jian A, Lo T, Desveaux D. (2012). A high-throughput forward genetic screen identifies genes required for virulence of Pseudomonas syringae pv. maculicola ES4326 on Arabidopsis. PLoS One 7(8):e41461.
Lee A.H., Hurley B., Felsensteiner C., Yea C., Ckurshumova W., Bartetzko V., Wang P.W., Quach V., Lewis J.D., Liu Y.C., Bornke F., Angers S., Wilde A., Guttman D.S. and Desveaux D. (2012). A bacterial acetyltransferase destroys plant microtubule networks and blocks secretion. PLoS Pathogens 8(2):e1002523.
Lewis J.D., Wan J., Ford R., Gong Y., Fung P., Nahal H., Wang P.W., Desveaux D.* and Guttman D.S.* (2012). Quantitative interactor screening with next-generation sequencing (QIS-Seq) identified Arabidopsis thaliana MLO2 as a target of the Pseudomonas syringae type III effector HopZ2. BMC Genomics Jan 9; 13:8.*corresponding authors
2011
Lewis J.D., Lee A., Ma W., Zhou H., Guttman D.S. and Desveaux D. (2011). The YopJ superfamily in plant associated bacteria. Molecular Plant Pathology 12(9):928-937.
Cao F.Y., Yoshioka K. and Desveaux D. (2011). The roles of ABA in plant-pathogen interactions. Journal of Plant Research 124(4): 489-499..
Schreiber K.J. and Desveaux D. (2011). AlgW regulates multiple Pseudomonas syringae virulence strategies. Molecular Microbiology 80(2): 364-377..
Schreiber K.J., Nasmith C.G., Allard G., Singh J., Subramaniam R. and Desveaux D. (2011). Found in translation: High-throughput chemical screening in Arabidopsis thaliana identifies small molecules that reduce Fusarium head blight in wheat. Molecular Plant-Microbe Interactions 24(6):640-648..
O’Brien H.E., Desveaux D. and Guttman D.S. (2011). Next-generation genomics of Pseudomonas syringae. Current Opinion in Microbiology 14(1): 24-30.
2010
Wilton M. and Desveaux D. (2010). Lessons learned from type III effector transgenic plants. Plant Signaling and Behavior 5(6):746-8.
Lewis J.D., Wu R., Guttman D.S. and Desveaux D. (2010). Allele-specific virulence attenuation of the Pseudomonas syringae HopZ1a type III effector via the Arabidopsis ZAR1 resistance protein. PLoS Genetics. 6(4):e1000894.
Wilton M., Subramaniam R., Elmore J., Felsensteiner C., Coaker G., and Desveaux D. (2010). The type III effector HopF2Pto targets Arabidopsis RIN4 protein to promote Pseudomonas syringae virulence. Proceedings of the National Academy of Sciences USA 107:2349-2354.
McCourt P. and Desveaux D. (2010). Plant Chemical Genetics. New Phytologist. 185:15-26.
2009
Lewis J.D., Guttman D.S., and Desveaux D. (2009). The targeting of plant cellular systems by injected type III effector proteins. Seminars in Cell Developmental Biology. 20:1055-63.
Lewis J.D, Schreiber K. and Desveaux D. (2009). The needle and the damage done: type III effectors and the plant immune response. Book Chapter Molecular Plant-Microbe Interactions, 179-210. Eds. Bouarab K., Brisson N., Daayf F.
Park S.Y., Fung P., Nishimura N., Jensen D.R., Fujii H., Zhao Y., Lumba S., Santiago J., Rodrigues A., Chow T.F., Alfred S.E., Bonetta D., Finkelstein R., Provart N.J., Desveaux D., Rodriguez P.L., McCourt P., Zhu J.K., Schroeder J.I., Volkman B.F., and Cutler S.R. (2009). Abscisic acid inhibits type 2C protein phosphatases via the PYR/PYL family of START proteins. Science. 324:1068-71.
2008
Schreiber K., and Desveaux D. (2008). Message in a Bottle: Chemical Biology of Induced Disease Resistance in Plants. Plant Pathology Journal. 24(3): 245-268.
Schreiber K., Ckurshumova W., Peek J. and Desveaux D. (2008). A high-throughput chemical screen for resistance to Pseudomonas syringae in Arabidopsis. Plant Journal. 54:522-31.
Lewis J.D., Abada W., Ma W., Guttman D.S. and Desveaux D. (2008). The HopZ family of Pseudomonas syringae type III effectors require myristoylation for virulence and avirulence functions in Arabidopsis. Journal of Bacteriology. 190:2880-2891.
Pre-2008
Desveaux D., Singer A.U., Wu A.J., McNulty B.C., Musselwhite L., Nimchuk Z., Sondek J. and Dangl J.L. (2007). Type III Effector Activation via Nucleotide Binding, Phosphorylation and Host Target Interaction. PLoS Pathogens. 3:456-469.
Nimchuk Z.L., Fisher E.J., Desveaux D., Chang J.H. and Dangl J.L. (2007). The HopX (AvrPphE) fanily of Pseudomonas syringae type III effectors require a catalytic triad and a novel N-terminal domain for function. Molecular Plant-Microbe Interactions. 20:346-357.
Desveaux D. , Singer A.U. and Dangl J.L. (2006). Type III effector proteins: doppelgangers of bacterial virulence. Current Opinion in Plant Biology 9: 376-382.
Kim H.S., Desveaux D., Singer A.U., Patel P., Sondek J. and Dangl J.L. (2005). The Pseudomonas syringae effector AvrRpt2 cleaves its C-terminally acylated target, RIN4, from Arabidopsis membranes to block RPM1 activation. Proceedings of the National Academy of Sciences 102:6496-501.
Desveaux D. , Marechal A. and Brisson N. (2005). Whirly transcription factors: defence gene regulation and beyond. Trends in Plant Science 10:95-102.
Singer A.U., Desveaux D., Betts L., Chang J.H., Nimchuk Z., Grant S.R., Dangl J.L. and Sondek J (2004). The Crystal Structure of the Type III Effector AvrPphF Reveals Residues Required for Both Virulence and Avirulence Functions. Structure 12:1669-1681.
Desveaux D. , Subramaniam R., Després C., Mess J.-N., Lévesque C., Fobert P.R., Dangl J.L. and Brisson N. (2004). A “Whirly” Plant Transcription Factor is Required for Salicylic Acid-Dependent Disease Resistance in Arabidopsis. Developmental Cell 6: 229-240.
Després C., Chubak C., Rochon A., Clark R., Bethune T., Desveaux D. and Fobert P.R. (2003). The Arabidopsis NPR1 Disease Resistance Protein Is a Novel Cofactor That Confers Redox Regulation of DNA Binding Activity to the Basic Domain/Leucine Zipper Transcription Factor TGA1. Plant Cell 15: 2181-2191.
Desveaux D. , Allard, J., Brisson, N. and Sygusch, J. (2002). A new family of plant transcription factors displays a novel ssDNA-binding surface. Nature Structural Biology 9: 512-517.
Desveaux D. , Allard J., Brisson, N. and Sygusch J. (2002). Crystallization and preliminary x-ray crystallographic analysis of p24, a component of the potato nuclear factor PBF-2. Acta Crystallographica, Section D: Biological Crystallography 58: 296-298.
Subramaniam R., Desveaux D., Spickler C., Michnick S. and Brisson N. (2001). Direct visualization of protein interactions in plant cells. Nature Biotechnology 19: 769-772
Desveaux D. , Després C., Joyeux A., Subramaniam R. and Brisson N. (2000). PBF-2 is a novel single-stranded DNA binding factor implicated in PR-10a gene activation. Plant Cell 12: 1477-1489.
Faik A, Desveaux D. and MacLachlan G. (2000). Sugar-nucleotide-binding and autoglycosylating polypeptide(s) from nasturtium fruit: biochemical capacities and potential functions. Biochemical Journal 347 Pt 3:857-64.
Desveaux D, Faik A. and Maclachlan G. (1998). Fucosyltransferase and the biosynthesis of storage and structural xyloglucan in developing nasturtium fruits. Plant Physiology 118(3):885-94.
Faik A, Desveaux D. and MacLachlan G. (1998). Enzymic activities responsible for xyloglucan depolymerization in extracts of developing tomato fruit. Phytochemistry 49(2): 365-376.